Synthetic oligonucleotides as therapeutic agents
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چکیده
منابع مشابه
Synthetic oligonucleotides as therapeutic agents.
Currently there is much excitement in certain quarters about antisense oligonucleotides, both as the drugs of the future for treatment of cancer and viral infections, most notably AIDS, and also as genetic tools for generating mutant phenocopies without genomic mutation in investigations of mammalian gene function. The extent of this excitement is reflected in the proliferation of antisense bio...
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Because of the specificity of Watson-Crick base pairing, attempts are now being made to use oligodeoxynucleotides (oligos) in the therapy of human disease. However, for a successful outcome, the oligo must meet at least six criteria: (i) the oligos can be synthesized easily and in bulk; (ii) the oligos must be stable in vivo; (iii) the oligos must be able to enter the target cell; (iv) the olig...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1991
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1991.3